The more lipid soluble the barbiturate, the more rapidly it penetrates all tissues of the body. Barbiturates are bound to plasma and tissue proteins to a varying degree with the degree of binding increasing directly as a function of lipid solubility.
Has been used to ameliorate or prevent sequelae associated with cerebral ischemia during neurosurgical procedures† [Chiuso-label] that require long periods of cerebral hypoxia.
Reports of infants suffering from long-term barbiturate exposure in utero included the acute withdrawal syndrome of seizures and hyperirritability from birth to a delayed onset of up to 14 days. (See “Drug Abuse And Dependence” section.)
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Hypnotic doses of these barbiturates do not appear to significantly impair uterine activity during labor. Full anesthetic doses of barbiturates decrease the force and frequency of uterine contractions. Administration of sedative-hypnotic barbiturates to the mother during labor may result Per respiratory depression Durante the newborn.
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Pentobarbital is not used widely in clinical medicine because of its poor safety website profile, habituation, and lack of an antidote. All prescribing clinicians should be aware of the drug's toxicity and adverse event profile. Neurologists can use pentobarbital for refractory status epilepticus.
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If your symptoms or health problems do not get better or if they become worse, call your doctor. Do not share your drugs with others and do not take anyone else's drugs. Keep all drugs Sopra a safe place. Keep all drugs out of the reach of children and pets. Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs.
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There is anzi che read more no antidote for pentobarbital and overdose treatment is symptomatic and supportive. Treatment may require intubation and respiratory support, maintenance of blood pressure with medication and fluids, and maintenance of body temperature.